Originally developed to help diabetics control their blood sugar, the study that put semaglutide for weight loss on the map — and compelled the FDA to approve its use for weight loss — was a remarkable 2021 research paper published in the New England Journal of Medicine.

Here are the highlights of the study:

• Researchers followed roughly 2,000 obese (defined as BMI over 30) individuals for 68 weeks
• Some participants were given a weekly dose of 2.4 milligrams of semaglutide (the experimental group) and the others were given a placebo (the control group)
• The group receiving semaglutide lost an average of a whopping 14.9% of their total body weight over 68 weeks; the placebo group only lost 2.4%. The chart below illustrates the stark contrast between the semaglutide group and the control group, demonstrating the impressive performance of semaglutide for weight loss.

Source: New England Journal of Medicine

Subsequent studies from highly reputable institutions have found more of the same in the way of semaglutide’s effectiveness for achieving significant weight loss — for example, via the Journal of the American Medical Association:

“This cohort study, conducted at a referral center for weight management, retrospectively collected data on the use of semaglutide for adults with overweight or obesity between January 1, 2021, and March 15, 2022, with a follow-up of up to 6 months. A total of 408 patients with a body mass index (BMI) of 27 or more were prescribed weekly semaglutide subcutaneous injections for 3 months or more.

This study is the first retrospective study to evaluate weight loss outcomes associated with treatment with subcutaneous semaglutide, including the highest doses approved for weight loss (>1.0 mg) for patients with overweight or obesity, with or without type 2 diabetes. In our cohort, patients lost approximately 6.7 kg at 3 months and 12.3 kg at 6 months, equivalent to 5.9% of weight lost at 3 months and 10.9% of weight lost at 6 months.”

10-15% reductions in body weight, as seen in these studies, are significant achievements, as anyone who has battled excess body fat can attest.

The weight loss benefits of semaglutide accrue with time, with the option always available of adjusting dosing as necessary to meet your weight loss goals. (See “Semaglutide Dosing” section for expert dosing guidelines.)

Because the research shows that injectable semaglutide is far more effective for weight loss than oral semaglutide (pills), we only offer injectable semaglutide at Ozempic Near Me.

The vast majority of clinical studies confirming semaglutide’s efficacy for weight loss, including the ones in our “Semaglutide Research” section, use injectable semaglutide (often described as “subcutaneous” injections, meaning “under the skin”).

Medicine Matters weighs in on the debate over injectable vs. oral semaglutide:

“Like the injectable preparations [oral semaglutide] does cause some weight loss; however, it should be noted that these therapeutic benefits were achieved using the highest dose of 14 mg daily, and are not as great as is seen with injectable semaglutide at the 1 mg once-weekly dose…

Oral semaglutide is slightly less efficacious than the injectable preparation, requires daily compared with weekly administration, with careful attention to detail in relation to administration, and does not currently have data that unequivocally support cardiovascular benefit.”

In summary:

• Oral semaglutide is not sufficiently absorbed through the gastrointestinal tract, resulting in waste; injectable semaglutide is delivered directly under the skin and fully absorbed
• Oral semaglutide only produces marked weight loss effects if used in extremely high doses; injectable semaglutide achieves greater weight loss results with less than 1/10 of the dose, resulting in substantial financial savings
• Oral semaglutide must be taken every day, as compared to once-weekly semaglutide injections (in most cases)
• Oral semaglutide does not demonstrate any cardiovascular (heart) benefits; injectable semaglutide, on the other hand, does demonstrate cardiovascular benefits

It’s important to understand that the FDA carefully weighed the relative costs and benefits of semaglutide before it approved the medication for weight loss in 2021, concluding that the upsides outweigh the possible downsides.

That said, patients taking advantage of semaglutide’s weight loss benefits should be aware of potential side effects of the medication, which commonly include:

• Fatigue
• Diarrhea
• Stomach pain/stomach cramps
• Heartburn
• Blurry vision
• Vomiting

The majority of side effects associated with compounded semaglutide are mild and correctable with dose adjustments and possibly medication as necessary.

“The side effects of semaglutide are typically mild — especially when compared to the complications associated with overweight and obesity,” notes UCLA Health. “You may be able to reduce the side effects by beginning on a lower dose and then slowly increasing the amount you take.”

By following our individualized, data-driven dosing guidelines (see “Semaglutide Dosing” section for more information), our weight loss patients successfully avoid most side effects.

At Ozempic Near Me, we offer patients exclusive pricing on our superior compounded semaglutide for weight loss at various doses so you can get exactly the proper dose you need to meet your weight loss goals at the right cost.

2.5 mg Semaglutide Injections: $195

Our 2.5 mg specially compounded semaglutide package, which costs about 1/10 of a month’s supply of brand-name semaglutide like Ozempic, includes:

• 1 vial of 2.5 mg/ml high-potency compounded semaglutide in a 1 ml vial
• Syringes
• Alcohol
• Dosing guide
• Ongoing support from our staff to answer any questions you have regarding dosing, administration of the product, side effects, etc.

7 mg Semaglutide Injections: $350

With the purchase of 1 vial of 1 mg/ml in a 7ml vial at $350, you’ll also receive standard:

• Syringes
• Alcohol
• Dosing guide
• Ongoing support from our staff to answer any questions you have regarding dosing, administration of the product, side effects, etc.

10 mg Semaglutide Injections: $450

For $450, you get 1 vial of 5 mg/ml in a 2ml vial, totaling 10 mg of specially compounded semaglutide, plus:

• Syringes
• Alcohol
• Dosing guide
• Ongoing support from our staff to answer any questions you have regarding dosing, administration of the product, side effects, etc.

20 mg Semaglutide Injections: $625

The greatest per-mg value is our 20 mg specially compounded semaglutide (1 vial of 5 mg/ml in a 4ml vial) for just $625, which comes with:

• Syringes
• Alcohol
• Dosing guide
• Ongoing support from our staff to answer any questions you have regarding dosing, administration of the product, side effects, etc.

Bear in mind that the same 20 mg of brand-name Ozempic or Wegovy could easily cost in excess of $6,000 — with no additional clinical benefit over specially compounded semaglutide. Don’t waste your money!

Semaglutide therapy for weight loss typically requires once-weekly injections, although patients might require more or less frequent dosing depending on each individual’s weight loss goals and current health status.

As with most drugs, to achieve optimal results and to minimize any chance of side effects, most semaglutide patients follow an escalating dosing schedule, beginning with a relatively small dose and working towards incrementally higher doses until desired weight loss is achieved.

We’re always available to assist our customers with expert advice concerning any dosing issues that pop up during therapy, so don’t hesitate to reach out. We’re here to ensure your weight loss success, and we have significant experience doing so.

As a general rule, let’s look at standard dosing regimens for patients using specially compounded semaglutide for weight loss.

Semaglutide 2.5 mg Dosing Schedule

Here’s the standard dosing schedule for a 2.5 mg vial of specially compounded semaglutide over a 7-week period:

Please see our 2.5 mg sample dosing schedule for reference.

Semaglutide 7 mg Dosing Schedule

Below is the standard dosing regimen for our 7 mg vial of specially compounded semaglutide across a 12-week period:

Please see our 7 mg sample dosing schedule for reference.

Semaglutide 10 mg Dosing Schedule

Below is the standard dosing schedule for our 1 vial of 5 mg/ml in a 2ml vial (10mg total) compounded semaglutide over 14 weeks:

Please see our 10 mg sample dosing schedule for reference.

Semaglutide 20 mg Dosing Schedule

Here is the typical dosing regimen for our 1 vial of 5 mg/ml in a 4ml vial (total of 20 mg) compounded semaglutide over an 18-week period:

Please see our 20 mg dosing schedule for reference.